Table 1 Characteristics of the subjects included in the entire present study.

N

3024

2554

1521

1328

Female (%)

46.30

45.97

40.30

40.44

Age (mean ± SD)

52.35 ± 11.54

53.55 ± 11.49

46.00 ± 11.13

46.50 ± 11.22

Local reaction (%)

 Pain in vaccination site

86.67

82.34

86.52

80.57

 Vaccination site becomes red

10.35

13.78

33.99

37.65

 Swelling of vaccination site

18.78

21.34

40.37

42.02

 Vaccination site becomes hard

11.71

11.82

21.04

19.73

 Itching of vaccination site

8.80

11.39

26.89

26.05

 Vaccination site becomes hot

17.72

17.42

37.74

38.03

 Movement disorder (can’t raise the arm) at the vaccination site

23.54

19.73

30.18

25.53

 Internal bleeding in vaccination site

1.39

0.78

0.99

1.20

 There is nothing that applies in this

7.28

9.98

4.01

8.28

Systemic reaction (%)

 37.5 degrees Celsius or higher fever

6.58

36.22

17.75

83.21

 38 degrees Celsius or higher fever

1.55

15.94

5.85

58.81

 Fatigue

24.64

48.83

35.44

70.86

 Chills (pathological)

2.55

11.47

6.44

37.12

 Hot flash

4.83

8.89

7.30

15.44

 Peripheral coolness (cold of hands and feet)

0.56

1.33

0.72

4.74

 Numbness

1.65

1.53

2.76

2.48

 Shivering

0.20

1.02

1.12

4.59

 Dizzy

1.72

2.98

2.10

5.72

 Headache

11.57

25.29

15.71

43.37

 Sore throat

0.69

0.74

0.72

1.96

 Mouth and throat discomfort

1.09

1.25

1.18

2.33

 Back pain

1.22

4.46

2.96

9.56

 Swelling of lymph nodes (especially neck, armpit, inguinal part)

0.73

2.51

2.24

1.96

 Pain of lymph nodes (especially neck, armpit, inguinal part)

1.39

4.03

3.88

5.87

 Chest pain

0.73

1.10

1.25

1.20

 Stomach ache

0.76

1.21

0.79

1.81

 Abdominal discomfort

1.22

1.41

0.79

2.11

 Eye pain

0.40

0.55

0.46

1.43

 Joint pain

3.64

11.55

5.85

23.64

 Muscle pain

9.95

12.14

13.54

19.43

 Musculoskeletal discomfort (such as muscle tension)

1.55

3.05

1.84

3.84

 Limb pain

1.06

1.92

1.05

3.16

 Limb discomfort

0.50

1.17

0.66

1.96

 Snot

1.06

0.98

0.99

1.81

 Stuffy nose

0.66

0.55

0.53

1.20

 Nausea

1.65

2.47

1.97

4.52

 Vomiting

0.23

0.43

0.59

1.13

 Loss of appetite

1.16

4.50

2.70

14.83

 Diarrhea

1.92

2.70

2.17

3.46

 Loose stool

0.83

1.61

0.72

1.58

 Constipation

0.23

0.39

0.33

0.23

 Cough

0.60

0.43

0.59

1.58

 Sneeze

0.33

0.35

0.46

0.45

 Dyspnea

0.17

0.04

0.20

0.38

 Muscle weakness

0.33

0.67

0.13

1.36

 Stomatitis

0.40

0.63

0.26

0.98

 Urticaria (rash that disappears within a few hours)

0.36

0.63

0.33

0.60

 Eczema (long-term rash)

0.17

0.43

0.72

0.53

 Blunt feeling

0.50

0.51

0.85

1.43

 Sleepy in the daytime

5.19

8.22

4.93

9.94

 Insomnia

0.43

0.82

0.66

1.28

 Hyperhidrosis

0.43

0.74

0.33

1.28

 There is nothing that applies in this

56.35

29.44

43.26

4.37