Table 3 Allele frequency and expression quantitative trait locus (eQTL) genes of the loci associated with the COVID-19 vaccine adverse events.

From: A web-based genome-wide association study reveals the susceptibility loci of common adverse events following COVID-19 vaccination in the Japanese population

Variant

Associated reaction

Location

Allele frequency

eQTL genes

European

Japanese

rs10744866

Itching at vaccination site

12q24

0.20

0.37

MVK, FOXN4, KCTD10

rs146922515

Movement disorder at vaccination site

10p12

0.35

0.43

None in GTEx

rs1217097

Internal bleeding at vaccination site

8q12

0.28

0.24

RP11-579E24.2, LINC01289

rs551634406

37.5 °C or higher fever

6p21

1.00

0.49

None in GTEx

rs183300

37.5 °C or higher fever

6p21

0.65

0.46

BAK1, COL11A2, DAXX, IP6K3

rs9266082

38 °C or higher fever

6p21

0.30

0.39

C4B, CCHCR1, CSNK2B, HCG22, HCG27, HLA-B, HLA-C, HSPA1B, MICB, MIR6891, NOTCH4, POU5F1, PSORS1C1, PSORS1C2, RNF5, SFTA2, TCF19, USP8P1, VARS2, VWA7, WASF5P, XXbac-BPG181B23.7, XXbac-BPG248L24.12, XXbac-BPG299F13.17

rs375726766

38 °C or higher fever

6p21

0.60

0.36

None in GTEx

rs10205263

Peripheral coolness

2q35

0.071

0.09

No eQTL genes

rs67053119

Dizzy

8q11

0.12

0.075

No eQTL genes

rs13279405

Chest pain

8p22

0.24

0.056

No eQTL genes

rs57177321

Abdominal discomfort

11p13

0.072

0.1

No eQTL genes

rs34086990

Joint pain

8q21

0.042

0.19

None in GTEx

rs3135408

Muscle pain

6p21

0.54

0.36

B3GALT4, BAK1, DAXX, HCG24, HCG25, HLA-DPA1, RGL2, RPS18, TAPBP, WDR46, ZBTB22

rs2274569

Urticaria

1p21

0.076

0.064

DBT, LRRC39, MFSD14A, RTCA, SASS6, SLC35A3, TRMT13

  1. European allele frequency, the allele frequency of European individuals (non-Finnish) in gnomAD v2,1,1; Japanese allele frequency, allele frequency in this study; eQTL genes, Variants associated with the COVID-19 vaccine adverse events were associated with the gene expression in GTEx (p-value < 0.0005).
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