Table 4 HLA alleles identified by the HLA association analysis of the COVID-19 vaccine adverse events.
Reaction | HLA allele | Dose | BNT162b1 vaccine | mRNA-1273 vaccine | ||||
|---|---|---|---|---|---|---|---|---|
AF | OR | P | AF | OR | P | |||
Pain in vaccination site | DQA1*01:01 | 1st | 0.1 | 1.04 | 0.917 | 0.09 | 3.58 | 0.0002932 |
2nd | 0.09 | 1.72 | 0.2394 | 0.09 | 1.22 | 0.3588 | ||
Pain in vaccination site | DQB1*05:01 | 1st | 0.1 | 1.15 | 0.3469 | 0.08 | 3.05 | 0.000443 |
2nd | 0.06 | 1.27 | 0.1741 | 0.08 | 1.33 | 0.1802 | ||
Swelling of lymph nodes (especially neck, armpit, inguinal part) | B*15:02 | 1st | 0.12 | 4.35 | 0.00008469 | NA | NA | NA |
2nd | NA | NA | NA | NA | NA | NA | ||
37.5 °C or higher fever | DPB1*09:01 | 1st | 0.15 | 0.84 | 0.383 | 0.1 | 0.97 | 0.8852 |
2nd | 0.15 | 0.65 | 0.0003488 | 0.1 | 1.04 | 0.8483 | ||
37.5 °C or higher fever | B*40:06 | 1st | 0.07 | 1.03 | 0.8866 | 0.06 | 1.22 | 0.4482 |
2nd | 0.13 | 0.67 | 0.0002165 | 0.06 | 0.84 | 0.5695 | ||
37.5 °C or higher fever | DQB1*06:01 | 1st | 0.19 | 1.11 | 0.7392 | 0.21 | 0.87 | 0.2867 |
2nd | 0.13 | 0.62 | 0.000009773 | 0.21 | 0.9 | 0.4149 | ||
37.5 °C or higher fever | DRB1*11:01 | 1st | 0.07 | 0.52 | 0.04899 | NA | NA | NA |
2nd | 0.14 | 0.63 | 0.0001659 | NA | NA | NA | ||
37.5 °C or higher fever | DQA1*06:01 | 1st | NA | NA | NA | NA | NA | NA |
2nd | 0.2 | 0.7 | 0.00007333 | NA | NA | NA | ||
Muscle pain | DRB1*11:01 | 1st | 0.07 | 0.79 | 0.3191 | NA | NA | NA |
2nd | 0.14 | 0.47 | 0.0002821 | NA | NA | NA | ||
Limb pain | DQA1*05:03 | 1st | NA | NA | NA | NA | NA | NA |
2nd | 0.07 | 3.27 | 0.0004283 | NA | NA | NA | ||
Sneeze | A*11:01 | 1st | 0.08 | 6.86 | 0.0003181 | 0.09 | 5.53 | 0.0124 |
2nd | 0.11 | 1.53 | 0.5975 | 0.09 | 1.38 | 0.7743 | ||
Muscle weakness | DQB1*03:01 | 1st | 0.1 | 1.85 | 0.5959 | 0.12 | 5.95 | 0.1866 |
2nd | 0.08 | 1.13 | 0.8376 | 0.11 | 4.42 | 0.0001313 | ||
Sleepy in the daytime | B*15:35 | 1st | NA | NA | NA | NA | NA | NA |
2nd | 0.12 | 1.74 | 0.0003864 | NA | NA | NA | ||
There is nothing that applies in this (systemic reaction) | DQA1*01:02 | 1st | 0.21 | 1.57 | 0.05491 | 0.19 | 1.7 | 0.000006869 |
2nd | 0.21 | 1 | 0.9944 | 0.18 | 1.09 | 0.7831 | ||
Chills (pathological) | DQA1*03:01 | 1st | 0.15 | 0.95 | 0.8494 | 0.1 | 0.9 | 0.7486 |
2nd | 0.12 | 1.39 | 0.02235 | 0.1 | 1.83 | 0.0005086 | ||
