Table 2 Procoagulant and anticoagulant markers used in the design of procoagulant score.

From: Investigation of thrombin concentration at the time of clot formation in simultaneous thrombin and fibrin generation assays

Procoagulant Markers (each one adds 1 to PS)

Normal Plasma addition to deficient plasma

FVIIa addition

FVIIa ≥ 200 nM

FVIIa Mutant ≥ 200 nM

TF ≥ 1 pM

TF ≥ 5 pM

FXIa ≥ 1 pM addition

FIX ≥ 0.1 IU/ml addition

FIX ≥ 0.25 IU/ml addition

FIXa ≥ 0.0016 IU/ml addition

Immune Globulins addition

Platelet Microvesicles addition

TG Phospholipids > 4 μM

Prothrombin Complex Concentrate > 0.25 IU/ml

Anticoagulant Markers (each one subtracts 1 from PS)

FVIII or FIX Deficient Plasma

No TF

TG Phospholipids < 4 μM

Non-Standard Calcium concentration (out of the range 10–12 mM)

Antithrombin ≥ 0.5 IU/ml addition

Apixaban

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