Figure 5
From: Genetic determinants of severe COVID-19 in young Asian and Middle Eastern patients: a case series
Pathway analysis and transcriptomic profiling. (A) Pathway enrichment analysis was performed for the genes with rare variants in severe COVID-19 patients. X-axis represents fold enrichment (the percentage of genes belonging to a pathway, divided by the corresponding percentage in the background); size of the circle represents number of genes enriched in a pathway. (B) Protein–Protein Interaction (PPI) network representation of the genes with rare variants in severe COVID-19 patients. Nodes represent proteins, and edges represent confidence of interaction based on functional and curated evidence (See “Methods” section). (C) Log2fold change value with adjusted p value < 0.001 of genes dysregulated in transcriptomic analysis when compared with controls.
