Table 2 Measures of agreements between SwissADME and pkCSM tools.
S.no. | Percentage of agreement (percentage) | Cohen’s Kappa (95% confidence interval) | Interpretation of Kappa |
|---|---|---|---|
Intestinal absorption | 100% | 1 | Strong agreement |
BBB permeant | 31% | − 0.11 (− 0.13 to − 0.10) | No agreement |
Pgp substrate | 92% | 0.2 (0.05 to 0.45) | Slight agreement |
CYP1A2 inhibitor | 79% | 0.53 (0.51 to 0.56) | Moderate agreement |
CYP2C19 inhibitor | 52% | − 0.05 (− 0.09 to − 0.009) | No agreement |
CYP2C9 inhibitor | 44% | 0.06 (0.04 to 0.09) | No agreement |
CYP2D6 inhibitor | 93% | 0.31 (0.10 to 0.53) | Fair agreement |
CYP3A4 inhibitor | 95% | 0 (− 0.62 to 0.62) | No agreement |
