Figure 5

Preliminary exploration of the LUAD immunophenotype and immune cell infiltration between high and low PBK expression. (A) Comparison of indicators of immune infiltration levels (both immune score and stromal score) between PBK high and low expression obtained by ESTIMATE using Kruskal–Wallis test. (B) Subgroup bar stacked plots showing an overview map of the distribution of immune infiltrative subtypes between PBK high and low expression groups. (C,D) The scores of 16 immune cells and 13 immune-related functions were detected by ssGSEA analysis, and the differences between different expression groups of PBK were demonstrated by box line plots. (E) Heat map demonstrating the expression of inflammatory, stromal-associated mRNAs in LUAD patients. (F) Grouped box line plot containing PBK expression, immune infiltrating subtypes and CNV mutation distribution. (G) Demonstration of PBK high and low expression between 28 representative immune cell profiles curated by Charoentong et al.