Table 1 Optimization for Synthesis of 2-amino-4H‐chromenea.

From: Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine

Entry

Solvent

Catalyst (mg)

t (min)

T (°C)

Yieldb (%)

1

EtOH

–

30

80

–

2

EtOH

Fe3O4@g-C3N4 (20)

30

80

28

3

EtOH

Fe3O4@ g-C3N4-PrBr (20)

30

80

32

4

EtOH

Fe3O4 (20)

30

80

Trace

5

EtOH

Captopril (20)

30

80

97

6

EtOH

Fe3O4@g-C3N4-Pr-Cap (20)

30

80

95

7

EtOH

Fe3O4@g-C3N4-Pr-Cap (30)

30

80

95

8

EtOH

Fe3O4@g-C3N4-Pr-Cap (10)

30

80

83

9

MeOH

Fe3O4@g-C3N4-Pr-Cap (20)

30

80

86

10

DMF

Fe3O4@g-C3N4-Pr-Cap (20)

30

80

73

11

H2O

Fe3O4@g-C3N4-Pr-Cap (20)

30

80

80

12

Solvent free

Fe3O4@g-C3N4-Pr-Cap (20)

30

80

44

13

EtOH

Fe3O4@g-C3N4-Pr-Cap (20)

30

50

95

14

EtOH

Fe3O4@g-C3N4-Pr-Cap (20)

30

25

82

15

EtOH

Fe3O4@g-C3N4-Pr-Cap (20)

15

50

95

  1. aReaction conditions: benzaldehyde (1.0 mmol), malononitrile (1.0 mmol), dimedone (1.0 mmol), and solvent (3.0 ml).
  2. bIsolated yield.
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