Table 4 Synthesis of 1,2,3,6-tetrahydropyrimidine derivatives using the catalysta.

From: Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine

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Entry

R

Products

Time (h)

Yieldb (%)

Mp (°C)

Observed

Literature

1

NO2

7a

8

86

169–171

–

2

F

7b

8

79

175–178

176–18350

3

Br

7c

8

69

162–165

164–16650

4

H

7d

8

80

167–169

166–16950

5

Me

7e

8

83

151–154

150–15350

  1. aReaction carried out with anilines (2.0 mmol), diethyl acetylenedicarboxylate (1.0 mmol) and benzaldehydes (1.2 mmol), in a 3.0 mL EtOH using 20 mg of the catalyst at 50 °C.
  2. bIsolated yield.
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