Table 3 Top pathways and GO enrichment terms of modules \(LC - MODUL^{C}\) related to the immune system in breast cancer subtype \(C\).
From: Exploring ceRNA networks for key biomarkers in breast cancer subtypes and immune regulation
Subtype \(C\) | Module’s Name | Type of RNAs in module | Go terms or Pathways | FDR |
|---|---|---|---|---|
HER2+ | C (Fig. 9) | lncRNA, mRNA | GO:2000409, positive regulation of T cell extravasation | 0.03519 |
Luminal B | F (Fig. 6) | lncRNA, mRNA | B cell receptor signaling pathway | 0.03837 |
Luminal B | G (Fig. 6) | lncRNA, mRNA | GO:0033083, regulation of immature T cell proliferation | 0.04753 |
Luminal B | H (Fig. 6) | lncRNA, mRNA | GO:0042110, T cell activation | 0.01656 |
Normal-like | B (Fig. 7) | lncRNA, mRNA | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.04297 |
Normal-like | B (Fig. 7) | lncRNA, mRNA | Adaptive Immune System | 0.04297 |
Normal-like | B (Fig. 7) | lncRNA, mRNA | T Helper Cell Surface Molecules | 0.04297 |
Basal-like | A (Fig. 5) | circRNA, mRNA | T Helper-2 activation | 0.03637 |
Luminal A | A (Fig. 8) | circRNA, mRNA | GO:0002819, regulation of adaptive immune response | 0.03149 |
Luminal A | C (Fig. 8) | circRNA, mRNA | GO:0002286, T cell activation involved in immune response | 0.02239 |
Luminal A | D (Fig. 8) | circRNA, mRNA | T cell activation | 0.0419 |
Luminal B | B (Fig. 6) | circRNA, mRNA | GO:0002765, immune response-inhibiting signal transduction | 0.04507 |
Luminal B | C (Fig. 6) | circRNA, mRNA | GO:1905399, regulation of activated CD4-positive, alpha–beta T cell apoptotic process | 0.009291 |
Luminal B | E (Fig. 6) | circRNA, mRNA | CD40/CD40L signaling | 0.07089 |
Normal-like | A (Fig. 7) | circRNA, mRNA | B cell receptor signaling pathway | 0.02161 |
