Figure 1 | Scientific Reports

Figure 1

From: Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy

Figure 1

Kinetic measurements: single cycle kinetics sensorgrams of a selection of the generated anti-CD44v6 IgG4 antibodies using SPR. Each antibody was captured by an immobilized anti-Fab antibody following injection of CD44iso4, in a fivefold serial dilution between 80 and 0.3 nM. Red lines represent the measured curves, while the black lines represent 1:1 kinetic binding model curve fits. appKD rather than KD is given for all these measurements to highlight a potential avidity contribution as a result of the dimeric form of the target protein used (Fc-fused).

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