Figure 2
From: MESIA: multi-epigenome sample integration approach for precise peak calling
Multi-Epigenome Sample Integration Approach for precise peak calling (MESIA) workflow. MESIA is executed using a two-stage strategy, where stage1 determines the reproducibility of multi-epigenome samples, and stage2 merges reproducible replications. A hypothetical replication A and replication B were grouped together to represent a replication set. If the replication set passes MESIA stage 1, the base peak of the replication set is derived and the replication set base peak, replication A, and replication B are filtered using the median of the peak point and Q value of the base peak. The high-ranking peak sets obtained in this way are merged to produce MESIA stage 2 passed multi replication peak. After repeating this process with several other replication sets and merging them, MESIA optimal peak is produced.
