Figure 7
From: Rhythmic profile of memory T and B-cells along childhood and adolescence
Integrative networks of memory T and B-cells along childhood and adolescence according to sex. Comprehensive networks were built for memory T-cell subsets (CD4+ and CD8+) and B-cells from healthy children and adolescents, categorized according to sex (Males (Blue color bar), n = 408 and Females (Red color bar), n = 404) followed by age stratification into distinct groups (9Mths–1Yr, n = 62, n = 73; 2Yrs, n = 67, n = 80; 3–4Yrs, n = 67, n = 62; 5–7Yrs, n = 72, n = 61; 8–10Yrs, n = 71, n = 69 and 11–18Yrs, n = 69, n = 59, respectively). Data analyses were carried out by Spearman rank tests as described in Material and Methods. Networks were built using cluster layouts comprising four groups of memory cell phenotypes, including: NAIVE (N), Early EFFECTOR (eEF), CENTRAL/NON-CLASSICAL (CM/nCM) and EFFECTOR/CLASSICAL MEMORY (EM/CM) subsets. Connecting edges identify positive (continuous line) and negative (dashed line) correlations. The line thickness illustrates the correlation strength, comprising weak/moderate (“r” scores from |0.1 to 0.67|, thin lines) and strong correlations (“r” scores from ≥|0.67|, thick lines). Common correlations axes are identified by blue/red lines and selective correlation axis observed at each age range are underscored by orange lines. The node sizes are proportional to the number of strong correlations between cell subsets. Memory cell phenotypes participating in at least 1 strong correlation are underscored by dark green nodes. The number of total and selective correlations between cell subsets at each age range as well as the number of common correlation axes along all age groups are provided in the figure. Circular backgrounds underscore the proportional contribution of each cell cluster to the overall connectivity at distinct age groups.
