Table 2 Between-group comparisons of hubs.

From: Association of executive function with suicidality based on resting-state functional connectivity in young adults with subthreshold depression

Brain region	Laterality	BA	No. of top 12%-ranked centralities (among the EC, BD, and DC)			Mean of eigenvector centrality (EC)			Mean of betweenness centrality (BC)			Mean of degree centrality (DC)			Group effects (P values)			Post-hoc pairwise comparisons
Brain region	Laterality	BA				Mean of eigenvector centrality (EC)			Mean of betweenness centrality (BC)			Mean of degree centrality (DC)			Group effects (P values)			HC versus StD (P values)			HC versus MDD (P values)			StD versus MDD (P values)			Between-group difference of Hubness
			HC	StD	MDD	HC	StD	MDD	HC	StD	MDD	HC	StD	MDD	EC	BC	DC	EC	BC	DC	EC	BC	DC	EC	BC	DC
Precuneus	R	5	3^a	3^a	2^a	0.67	1.28	0.63	0.81	1.15	0.52	0.80	1.21	0.44	0.033^b	0.123	0.008^b	0.038^b	NA	0.110	0.892	NA	NA	0.023^b	NA	0.003^b	StD > HC = MDD
Anterior dorsal dysgranular insula	L	–	1	3^a	1	0.71	1.48	0.61	0.17	0.80	0.29	0.45	1.27	0.50	0.007^b	0.063	0.007^b	0.011^b	NA	0.005^b	0.739	NA	NA	0.005^b	NA	0.008^b	StD > HC = MDD
Dorsomedial prefrontal cortex	R	6	1	3^a	0	0.53	1.22	0.48	0.32	0.50	0.18	0.30	0.94	0.31	0.022^b	0.450	0.047^b	0.031^b	NA	0.043^b	0.864	NA	NA	0.010^b	NA	0.020^b	StD > HC = MDD
Middle Temporal Gyrus	L	37	0	3^a	0	0.31	0.89	0.08	0.03	0.61	− 0.04	0.20	0.80	− 0.06	0.028^b	0.056	0.010^b	0.116	NA	0.080	0.417	NA	NA	0.012^b	NA	0.005^b	StD > HC = MDD
Postcentral Gyrus	L	1/2/3	1	2^a	3^a	0.47	0.92	1.13	0.55	0.28	1.13	0.44	0.75	1.23	0.073	0.007^b	0.014^b	NA	0.318	0.275	NA	0.056	0.056	NA	0.002^b	0.070	NS
Anterior sub-genual cingulate	L	32	2^a	0	0	0.17	− 0.49	− 0.31	0.58	− 0.03	0.23	0.67	0.05	0.21	0.003^b	0.017^b	0.006^b	0.005^b	0.010^b	0.005^b	0.040^b	0.116	0.116	0.204	0.146	0.346	MDD = StD < HC
Rostral temporal thalamus	R	–	2^a	0	0	0.66	0.05	− 0.23	0.12	0.34	− 0.31	0.59	0.08	− 0.23	0.009^b	0.049^b	0.010^b	0.064	0.503	0.079	0.006^b	0.061	0.061	0.260	0.029^b	0.204	NS

Group-level hubs that showed significant between-group differences of z-transformed centralities (degree, betweenness, and eigenvector) averaged in the network sparsity levels of K = 0.11–0.15 [that satisfied network connectedness, small-worldness, and modular organization in the resting-state functional connectivity network (rs-FCN) of all healthy controls (HC; N = 23)]. Only 47 brain regions (out of the 226 brain regions comprising the rs-FCN) ranked as group-level hubs either in HC (23 hubs), subthreshold depression (StD; N = 26, 27 hubs) or major depressive disorder (MDD; N = 30, 26 hubs) hubs underwent between-group comparisons. Threshold of statistical significance was set as P < 0.05 in 2–3 centralities.
L, Left cerebral hemisphere; R, Right cerebral hemisphere; BA, Brodmann area; EC, Eigenvector centrality; BC, Betweenness centrality; DC, Degree centrality; HC, Health control; StD, Subthreshold depression; MDD, Major depressive disorder.
^aGroup-level hubs.
^bP < 0.05.Significant values are in bold.

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Table 2 Between-group comparisons of hubs.

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