Figure 3
Receiver operating characteristic (ROC) curves in the diagnostic and prospective studies for the ARG1 candidate. (a) LC discrimination based on 128 cases and 62 FalsePos in the diagnostic study (NLCB). (b) LC discrimination based on 163 cases and 184 controls in the prospective studies (NOWAC and HUNT3). Six separate ROC curves are visualized for models including (i) smoking status/ variable only (“Smoking”), (ii) ARG1 expression only (“ARG1”), (iii) both the smoking status/ variable and ARG1 expression (“Smoking + ARG1”), (iv) both the smoking status/ variable and blood neutrophil estimates (“Smoking + Neu”), (v) the smoking status/ variable, blood neutrophil and CD4 T cell estimates (“Smoking + Neu + CD4T”) and (vi) the smoking status/ variable, blood neutrophil, CD4 T cell and NK cell estimates and candidate gene expression (“Smoking + Neu + CD4T + NK + ARG1”). ROC curves of the smoking status/ variable, blood neutrophil, CD4 T cell and NK cell estimates (“Smoking + Neu + CD4T + NK”) are not shown here, as they were very similar to the “Smoking + Neu + CD4T” ROC curves with almost identical AUC values. In the diagnostic study, smoking status was defined as never/ever smokers and in the prospective studies as smoking variable with seven categories combining smoking status (never/current/former) and pack-years (see Methods section for details).
