Table 4 Clinico-pathological associations of ATM mutant breast cancer patients.
Clinico-pathological variables | ATM mutant (nā=ā6) | ATM wildtype (nā=ā709) | p value |
|---|---|---|---|
n (%) | n (%) | ||
Age at diagnosis, years | |||
Ā MeanāĀ±āSD | 45āĀ±ā12.7 | 41.2āĀ±ā9.8 | Ā |
Ā Median (range) | 39 (32 ā 63) | 39.7 (13 ā 84) | Ā |
Ā āā¤ā50 | 4 (66.7) | 610 (86.0) | 0.2027 |
Ā ā>ā50 | 2 (33.3) | 99 (14.0) | Ā |
Family history of breast cancer | |||
Ā No | 2 (33.3) | 580 (81.8) | 0.0127 |
Ā Yes | 4 (66.7) | 129 (18.2) | Ā |
Bilateral breast cancer | |||
Ā Yes | 0 | 12 (1.7) | 1.0000 |
Ā No | 6 (100.0) | 697 (98.3) | Ā |
Lymph node status | |||
Ā Negative | 2 (33.3) | 258 (37.5) | 1.0000 |
Ā Positive | 4 (66.7) | 430 (62.5) | Ā |
Distant metastasis | |||
Ā Absent | 5 (83.3) | 623 (90.5) | 0.4522 |
Ā Present | 1 (16.7) | 65 (9.5) | Ā |
Stage | |||
Ā I | 0 | 98 (14.2) | 0.7233 |
Ā II | 3 (20.0) | 282 (41.0) | Ā |
Ā III | 2 (33.3) | 243 (35.3) | Ā |
Ā IV | 1 (16.7) | 65 (9.5) | Ā |
Histologic grade | |||
Ā Well differentiated | 0 | 48 (7.1) | 0.2026 |
Ā Moderately differentiated | 5 (83.3) | 317 (47.0) | Ā |
Ā Poorly differentiated | 1 (16.7) | 309 (45.9) | Ā |
Estrogen receptor status | |||
Ā Positive | 5 (83.3) | 388 (57.2) | 0.2479 |
Ā Negative | 1 (16.7) | 290 (42.8) | Ā |
Progesterone receptor status | |||
Ā Positive | 4 (66.7) | 356 (52.6) | 0.6889 |
Ā Negative | 2 (33.3) | 321 (47.4) | Ā |
Her-2 neu status | |||
Ā Positive | 2 (33.3) | 231 (34.6) | 1.0000 |
Ā Negative | 4 (66.7) | 437 (65.4) | Ā |
