Table 3 Association analysis between circulating PD-L1 cmRNA levels and KRAS4A cmRNA, KRAS4B cmRNA, KRAS mutational status and PD-L1 immunohistochemical expression.
Variable | Number of patients (%) | PD-L1 cmRNA levels Arithmetic mean (Cy0* value) | PD-L1 cmRNA levels 95% CI for the mean (Cy0* value) | Two-tailed probability |
|---|---|---|---|---|
High KRAS4A cmRNA | 28 (50) | 32.56 | 32.35–32.77 | p = 0.001 |
Low KRAS4A cmRNA | 28 (50) | 33.29 | 32.90–33.67 | |
High KRAS4A cmRNA | 31 (55) | 32.57 | 32.38–32.78 | p = 0.004 |
Low KRAS4A cmRNA | 25 (45) | 33.36 | 32.94–33.77 | |
KRAS wild-type | 43 (76) | 32.93 | 32.63–33.21 | p = 0.9 |
KRAS mutated | 13 (34) | 32.92 | 32.58–33.26 | |
PD-L1 ≥ 50% IHC | 28 (50) | 32.97 | 32.69–33.25 | p = 0.6 |
PD-L1 < 50% IHC | 28 (50) | 32.80 | 32.49–33.26 |
