Figure 4
VSV-S2 vaccinated hamsters cleared infectious virus in respiratory tissues. Infectious viral titer in (a) lung of vaccinated hamsters challenged with Alpha, (b) lung of vaccinated hamsters challenged with Delta, (c) nasal turbinate (NT) of vaccinated hamsters challenged with Alpha, and (d) NT samples of vaccinated hamsters challenged with Delta. Genomic viral RNA burden was determined by RT-qPCR in lung tissues from hamsters infected with (e) Alpha or (f) Delta. Genomic viral RNA burden was determined by RT-qPCR in NT from hamsters infected with (g) Alpha or (h) Delta. Ordinary one-way ANOVA followed by Turkey's multiple comparison test was used to determine significant differences. Data shown is mean ± SD of 6 hamsters per VSV-S2 group and 5 hamsters per VSV-WT groups. For all analyses, differences were considered to be significant with p < 0.05. Statistical significance was indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.
