Table 3 Subgroup and sensitivity analyses of patients with hypernatremia, hyponatremia and normonatremia at the time of ICU admission.
Hypernatremia | P-value | Hyponatremia | P-value | Normonatremia | |
|---|---|---|---|---|---|
Subgroup analyses–ICU mortality | |||||
Surgical patients | |||||
Frequency (%) | 462/3195 (14.5%) | 569/11,321 (5.0%) | 1848/55,564 (3.3%) | ||
Unadjusted OR (95% CI) | 4.91 (4.41–5.48) | < 0.001 | 1.54 (1.40–1.69) | < 0.001 | Reference |
Adjusted OR (95% CI) | 1.79 (1.54–2.07) | < 0.001 | 0.87 (0.77–0.98) | 0.026 | |
Medical patients | |||||
Frequency (%) | 1465/5903 (24.8%) | 4128/29,212 (14.1%) | 7061/56,831 (12.4%) | ||
Unadjusted OR (95% CI) | 2.33 (2.18–2.48) | < 0.001 | 1.16 (1.11–1.21) | < 0.001 | Reference |
Adjusted OR (95% CI) | 1.13 (1.04–1.22) | < 0.001 | 1.17 (1.11–1.23) | < 0.001 | |
Without neurological diseases | |||||
Frequency (%) | 1782/8187 (21.8%) | 4557/38,009 (12.0%) | 8155/95,594 (8.5%) | ||
Unadjusted OR (95% CI) | 2.98 (2.82–3.16) | < 0.001 | 1.46 (1.41–1.52) | < 0.001 | Reference |
Adjusted OR (95% CI) | 1.24 (1.15–1.33) | < 0.001 | 1.15 (1.10–1.21) | < 0.001 | |
With neurological diseases | |||||
Frequency (%) | 145/911 (15.9%) | 140/2524 (5.6%) | 754/16,801 (4.5%) | ||
Unadjusted OR (95% CI) | 4.03 (3.33–4.88) | < 0.001 | 1.25 (1.04–1.50) | 0.018 | Reference |
Adjusted OR (95% CI) | 1.65 (1.29–2.12) | < 0.001 | 0.85 (0.68–1.05) | 0.14 | |
Sensitivity analyses | |||||
Redefinition of normal serum sodium1 | |||||
Frequency (%) | 725/2717 (26.7%) | 1726/14,338 (12.0%) | 13,082/144,971 (9.0%) | ||
Unadjusted OR (95% CI) | 3.67 (3.36–4.00) | < 0.001 | 1.38 (1.31–1.46) | < 0.001 | Reference |
Adjusted OR (95% CI) | 1.20 (1.08–1.34) | 0.001 | 1.13 (1.06–1.21) | < 0.001 | |
Corrected sodium2 | |||||
Frequency (%) | 1838/10,728 (17.1%) | 2109/16,197 (13.0%) | 4808/61,264 (7.9%) | ||
Unadjusted OR (95% CI) | 2.43 (2.29–2.57) | < 0.001 | 1.76 (1.66–1.86) | < 0.001 | Reference |
Adjusted OR (95% CI) | 1.16 (1.07–1.25) | < 0.001 | 1.19 (1.12–1.28) | < 0.001 | |
