Figure 6
From: Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness
The AKT pathway contributes to POSTN regulation in the cancer microenvironment. (A) HEYA8 spheroid formation is disrupted under CMCTL and CMPOSTNhigh conditions when cells are treated with AKT inhibitor MK-2206, with more substantial disruption when the cells are cultured in CMPOSTNhigh. (B) AKT activation after treatment with AKT inhibitor MK-2206 is increased in HEYA8 cells cultured with CMPOSTNhigh compared to HEYA8 cells cultured with CMCTL. Western blots are shown using an anti-phospho-AKT antibody (top panel) or anti-total AKT antibody (middle panel). GAPDH was used as the internal loading control (bottom panel).
