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Figure 1

From: The longitudinal biochemical profiling of TBI in a drop weight model of TBI

Figure 1

Workflow implemented to explore brain metabolic alteration due to TBI. (a) Closed head injury model, experimental CHI was induced by using a weight-drop device method developed110 and modified111 by Shohami et al. (b) Sample collection, metabolite extraction and sample preparation for 1H NMR based metabolomics; (c) data collection and characterization of brain metabolic signatures by 1H NMR spectroscopy; (d) longitudinal statistical modelling and bioinformatic analysis of 1H NMR metabolomics data.

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