Figure 2
From: The longitudinal biochemical profiling of TBI in a drop weight model of TBI
(a) Score plot provided by factor analysis based on 1H NMR based metabolomics data associated with TBI biomarkers for disease severity and recovery exhibits an excellent separation. Factor analysis reveals the most discriminative metabolites driving the separation mainly are inosine, adenine, 2-hydroxyisovelarate, choline, isoleucine, and sn-glycero-3-phosphocholine. (b) Volcano plot comparing the metabolite concentration in mild TBI brain vs. sham control brain with fold change and associated statistical significance revealed Valine, Leucine, Tyrosine, Adenine and Histidine were the most affected metabolites; (c) Volcano plot comparing the metabolite concentration in severe TBI brain vs. sham control brain with fold change and associated statistical significance revealed Valine, Leucine, Inosine, Uracil and Adenine were the most affected metabolites; (d) Volcano plot comparing metabolite concentration in severe TBI brain vs. mild TBI brain has shown that Glucose-1-phosphate, Dimethylamine, NAA, and Creatinine were the metabolites showing statistically significantly largest concentration change; (e) enrichment analysis showing significantly perturbed metabolic pathways when mild TBI group is compared to sham controls and (f) enrichment analysis showing significantly perturbed metabolic pathways when the severe TBI group is compared to sham controls.
