Figure 4 | Scientific Reports

Figure 4

From: Natto consumption suppresses atherosclerotic plaque progression in LDL receptor-deficient mice transplanted with iRFP-expressing hematopoietic cells

Figure 4The alternative text for this image may have been generated using AI.

Natto consumption suppresses CCL2 expression in macrophages. (A) TMAO concentration in the serum from the mice in each group 9 weeks after induction. n = 6 for HCD, HCD + HVK, HCD + LVK. n = 3 for HCD + NN. (B) The concentrations of IL6, CCL2, TNFa in the serum from the mice in HCD and HCD + HVK 9 weeks after induction. n = 6 for HCD, HCD + HVK. (C) Relative mRNA expression level of CCL2 in the peritoneal macrophages with or without 3% HVK extract treatment. Values are normalized to the CT values of HPRT. (D–F) Relative mRNA expression level of IL-1b, IL-10, TNFα, IL6, IFNγ with or without HVK extract supplementation. (G–I) Relative mRNA expression level of CCL2, IL-1b, IL-10 after NN or LVK extract supplementation. (C–I) n = 6 in each group. Data are shown as mean +/− SEM. HCD: High-cholesterol diet. HVK High-vitamin K natto. LVK Low-vitamin K natto. NN Normal natto.

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