Table 1 Identification of the top 10 candidate drugs by using L1000FWD database.
Drug | Similarity score | p-value | q-value | Z-score | Combined score | MOA | Predicted MOA |
|---|---|---|---|---|---|---|---|
BRD-K92301463 | − 0.1111 | 2.01E-14 | 2.02E-10 | 1.81 | − 24.81 | Unknow | Dopamine receptor antagonist |
TG-101348 | − 0.1111 | 6.31E-13 | 1.92E-09 | 1.73 | − 21.16 | FLT3 inhibitor/JAK inhibitor | |
Cycloheximide | − 0.0992 | 1.59E-12 | 2.62E-09 | 1.89 | − 22.31 | Protein synthesis inhibitor | |
K784-3131 | − 0.0992 | 5.65E-12 | 7.33E-09 | 1.76 | − 19.84 | Unknow | EGFR inhibitor |
TWS-119 | − 0.0992 | 1.77E-11 | 1.57E-08 | 1.6 | − 17.23 | Glycogen synthase kinase inhibitor | |
BRD-K32644160 | − 0.0992 | 1.77E-11 | 1.57E-08 | 1.71 | − 18.39 | Unknow | P13K inhibitor |
H-7 | − 0.0992 | 2.01E-11 | 1.69E-08 | 1.68 | − 18 | Unknow | Dopamine receptor antagonist |
BRD-K74163137 | − 0.0913 | 2.31E-11 | 1.88E-08 | 1.75 | − 18.6 | Unknow | Dopamine receptor antagonist |
BRD-K00313977 | − 0.1032 | 2.82E-11 | 2.11E-08 | 1.71 | − 18.05 | Unknow | Dopamine receptor antagonist |
BRD-A62200266 | − 0.0952 | 3.12E-11 | 2.16E-08 | 1.75 | − 18.41 | Unknow | NFkB pathway inhibitor |
