Figure 3 | Scientific Reports

Figure 3

From: Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon

Figure 3

Comparison of key features in CRBN:MG:ZF1-2 complexes. (a) Representation of the location of ZF1 K389 atoms visible in structures for complexes CRBN:CC-220:ZF1-2(379–432) (magenta/orange/red) and CRBN:POM:ZF1-2(379–432) (green/red/cyan). Cereblon is not visible. (b) The locations of E377 in these complexes. ZF1-2 is omitted for clarity. (c) Comparison of the differences in locations of the NTD (left) and CTD (right) using corresponding residues F150 and E377, respectively. ZF1-2, pomalidomide, and CC-220 are omitted for clarity.

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