Figure 3
From: Evaluation of a decellularized bronchial patch transplant in a porcine model
A decellularized bronchus graft was well integrated with the native tissue and covered by an epithelial layer. Hematoxylin–Eosin (HE) staining for 7 days survival cases (a–c), 1 month survival cases (d–f), 2 months survival cases (g–i). Integration of the graft was observed at 1 month and 2 months post-operatively. The histological morphology was comparable/similar with that of 2 months control cases (j,k). At 7 days post-operatively, re-epithelialization is incomplete (b). At 1 month post-operatively, full re-epithelialization is observed (e). At 2 months post-operatively, a robust pseudostratified ciliated epithelial layer was observed in both decellularized bronchus graft patch (h) and control (k) at the location of the patch. The integrity of the cartilage within the patch is observed at 7 days and 1 month (c,f) with some degradation at 2 months in both experimental and control cases (i,l). Dotted line represents the junction between the native tissue and the graft.
