Figure 4
PRMT5 inhibition alters ECM organisation and differentiation of DMG cells. (A) The overlap between the genes differentially expressed between treatment groups for day 5 samples only, between treatment groups over the whole time course, or between day 0 and day 7. (B) The top 25 significant gene ontology (GO) terms enriched in the list of genes that were differentially expressed between treatment groups at day 5 (excluding those that were differentially expressed between days 0 and 7, but not the full time course. Similar terms have been removed). Terms selected for further validation are highlighted in yellow. (C) Volcano plots of differentially expressed genes at day 5 of the LLY-283 treatment where significantly changed genes are coloured yellow (padj < 0.05). Genes associated with the indicated GO terms are highlighted in red.
