Figure 6 | Scientific Reports

Figure 6

From: Gene expression alterations predict the pathological complete response in triple-negative breast cancer exploratory analysis of the NACATRINE trial

Figure 6

Graphical summary of the identification of differentially expressed genes as a pCR biomarker in a tissue biopsy specimen in the NACATRINE study. Step 1, genetic material was separated from tissue biopsy samples. Step 2 involved using a composite panel of breast cancer-related genes for gene expression profiling. Step 3 in the NACATRINE trial population, we identified a signature of 10 downregulated genes that have potential as accurate biomarkers for paclitaxel + carboplatin treatment, allowing differentiation between patients achieving pCR and those with RD. Furthermore, for the paclitaxel treatment arm, we identified 3 upregulated genes as potential pCR biomarkers.

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