Figure 5 | Scientific Reports

Figure 5

From: Emodin exhibits anti-acne potential by inhibiting cell growth, lipogenesis, and inflammation in human SZ95 sebocytes

Figure 5

Effects of emodin on acne-related pathological processes in SZ95 sebocytes. (A) Inhibition on cell proliferation by arresting the cell cycle in a PCNA-dependent manner. (B) Induction of apoptosis by downregulating Bcl-2 and upregulating Bax and caspase-3 cleavage. (C) Inhibition on IGF-1-induced lipogenesis by inhibiting the PI3K/Akt/FoxO1 pathway. (D) The inactivation of the NLRP3 inflammasome mitigates the production of pro-inflammatory cytokines IL-1β and IL-18 stimulated by C. acnes.

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