Table 4 Comparison of hemodynamic variables between baseline and 12th and 24th weeks after administration canagliflozin.
Hemodynamic variables | Baseline mean (SD) | 12-Week mean (SD) | p-value | 24-Week mean (SD) | p-value |
|---|---|---|---|---|---|
Heart rate (beats/min) | 75.0 ± 11.3 | 72.5 ± 13.2 | 0.043 | 71.5 ± 12.4 | 0.003 |
Systolic BP | 136.4 ± 15.4 | 135.0 ± 19.0 | 0.641 | 130.7 ± 14.8 | 0.019 |
Diastolic BP | 78.9 ± 11.3 | 77.5 ± 11.3 | 0.304 | 78.1 ± 12.2 | 0.469 |
Mean BP | 98.1 ± 11.4 | 96.7 ± 12.4 | 0.421 | 95.7 ± 11.1 | 0.109 |
Cardiac index | 2.5 ± 0.6 | 2.6 ± 0.6 | 0.022 | 2.9 ± 0.7 | < 0.001 |
Cardiac output (L/min) | 4.4 ± 1.0 | 4.7 ± 1.2 | 0.021 | 5.1 ± 1.5 | < 0.001 |
Stroke index[BSA] | 33.4 ± 6.4 | 36.6 ± 6.2 | < 0.001 | 40.3 ± 7.7 | < 0.001 |
Stroke volume (mL) | 59.6 ± 12.0 | 64.9 ± 11.3 | 0.001 | 71.8 ± 16.5 | < 0.001 |
Systemic vascular resistance index[BSA] | 3301.2 ± 788.5 | 3042.3 ± 873.5 | 0.014 | 2796.7 ± 797.3 | < 0.001 |
Thoracic fluid content | 24.6 ± 5.3 | 27.5 ± 6.1 | 0.009 | 32.7 ± 7.1 | < 0.001 |
Index of contractility (ICONTM) | 37.1 ± 12.7 | 44.6 ± 12.8 | < 0.001 | 49.2 ± 13.4 | < 0.001 |
Systolic time ratio | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.268 | 0.4 ± 0.1 | 0.705 |
Left ventricular ejection time (ms) | 295.8 ± 21.8 | 296.3 ± 25.5 | 0.842 | 296.4 ± 23.8 | 0.288 |
Pre ejection time (ms) | 108.5 ± 23.5 | 103.4 ± 21.0 | 0.161 | 107.1 ± 20.7 | 0.884 |
