Figure 11
From: Safety evaluation of PEGylated MNPs and p-PEGylated MNPs in SD rats
Genotoxicity potential of PEGylated MNPs and p-PEGylated MNPs. Comet assay were performed using peripheral nucleated cells and hepatocytes to investigate the DNA damage potential of PEGylated MNPs and p-PEGylated MNPs, and %tail DNA were evaluated to determine the extents of DNA breakage in blood samples(A) and hepatocytes(B) at different time points. In addition, Pig-a gene assay was performed to evaluate the gene mutation risk and the averaged RBCCD59- was counted using flow cytometry (C). ENU group was included as positive control. One-way ANOVA, comparing with the Control (Ctl),*p < 0.05.
