Table 1 Trends of activity of clotting factors and coagulation petameters, plasma protein and plasma properties from FFP to each hemofiltration.

From: Hemostatic capability of ultrafiltrated fresh frozen plasma compared to cryoprecipitate

Coagulation factors

FFP

50 mL removed

100 mL removed

200 mL removed

250 mL removed

Factor VIII (%)

108.7 ± 32.6

158.6 ± 60.0

194.1 ± 76.9*

264.8 ± 78.8*

308.7 ± 79.1*

Factor V (%)

92.0 ± 16.9

128.8 ± 25.8*

149.1 ± 34.6*

209.8 ± 49.6*

256.3 ± 61.6*

Factor IX (%)

108.6 ± 14.5

154.2 ± 25.2*

177.7 ± 28.6*

248.0 ± 42.7*

305.1 ± 54.8*

Factor XIII (%)

94.7 ± 18.5

130.6 ± 25.7*

143.7 ± 28.4*

192.0 ± 50.9*

213.7 ± 53.7*

VWF:RCo (IU/dL)

93.6 ± 26.2

124.5 ± 37.8

146.4 ± 41.8*

187.1 ± 50.9*

229.6 ± 71.8*

VWF:Ag (IU/unit)

113.8 ± 37.8

157.4 ± 62.8

188.1 ± 78.8*

251.5 ± 82.7*

275.7 ± 90.4*

Osmotic pressure (mOsm/kg/H2O)

288.2 ± 3.1

273.6 ± 6.5*

270.6 ± 3.4*

271.8 ± 3.2*

271.5 ± 9.3*

PT (s)

12.2 ± 0.6

11.4 ± 0.4*

11.3 ± 0.5*

11.0 ± 0.4*

11.1 ± 0.5*

APTT (s)

28.3 ± 2.2

27.6 ± 2.3

27.4 ± 2.4

27.5 ± 2.4

27.9 ± 2.4

Fibrinogen (mg/dL)

273.0 ± 69.7

388.1 ± 68.7*

454.5 ± 84.9*

631.1 ± 118.0*

716.9 ± 143.8*

Antithrombin (%)

96.4 ± 12.4

128.3 ± 15.8*

140.5 (14.8) *

 > 150*

 > 150*

Total protein (g/dL)

6.2 ± 0.3

8.3 ± 0.9*

9.5 ± 1.1*

13.1 ± 2.1*

15.9 ± 2.1*

Albumin (g/dL)

3.6 ± 0.3

5.0 ± 0.7*

5.8 ± 0.9*

7.7 ± 0.8*

8.8 ± 1.0*

The time during each filtration (min)

NA

279.7 ± 49.5

355.0 ± 85.4

813.6 ± 234.1

380 (273.8)

Plasma density

1.023 ± 0.001

1.029 ± 0.003*

1.033 ± 0.004*

1.041 ± 0.004*

1.047 ± 0.005*

EXTEM

 CT

59.3 ± 4.7

65.5 ± 13.0

70.1 ± 10.0

79.3 ± 22.0*

86.4 ± 14.6*

 CFT

NA

195.6 ± 207.7

117.1 ± 122.9

72.1 ± 34.1

69.1 ± 16.3

 α

77.9 ± 2.5

79.4 ± 2.3

79.5 ± 1.7

77.1 ± 7.9

75.8 ± 4.3

 MCF

21.1 ± 4.8

27.2 ± 4.7*

27.6 ± 4.9*

35.5 ± 5.7*

36.5 ± 8.2*

NATEM

 CT

824.4 ± 274.1

768.1 ± 198.7

703.3 ± 178.6

673.6 ± 193.3

650.7 ± 119.1*

 CFT

900.4 ± 457.3

248.0 ± 140.9*

267.3 ± 167.0*

157.5 ± 94.0*

154.2 ± 63.5*

 α

40.1 ± 13.2

55.7 ± 10.8*

54.1 ± 13.4*

62.1 ± 12.6

63.2 ± 8.4*

 MCF

22.1 ± 5.4

26.9 ± 3.6*

27.8 ± 4.7*

33.8 ± 4.5*

34.4 ± 5.8*

  1. Values are expressed as mean ± SD or median (range). Differences compared to baseline (*) are shown if results from two-way analysis of variance for repeated measures are significant (P < 0.05).
  2. FFP fresh frozen plasma, VWF:RCo von Willebrand factor ristocetin cofactor activity, VWF:Ag von Willebrand factor antigen, PT-INR prothrombin time-international normalized ratio, PT prothrombin time, APTT activated partial thromboplastin time, EXTEM extrinsic test, CT clotting time, CFT clot formation time, MCF maximum clot firmness, NATEM non-activated thromboelastometry, NA not assessed.
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