Table 2 Clinical measures and outcomes according to patient group.

From: MELD-Na score may underestimate disease severity and risk of death in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)

 

MASLD

N = 88

Viral hepatitis

N = 113

Alcoholic liver disease

N = 63

Alcoholic liver disease and Viral hepatitis N = 62

p-value

Follow-up duration (months), median (IQR)

53 (28.3–77.3)

59 (33.5–80)

56 (23–79)

47 (26–74)

0.33

Deceased, No. (%)

49 (55.7)

49 (43.4)

30 (47.6)

24 (38.7)

0.17

Death age, mean ± SD

70 ± 11.7

64.6 ± 11.7

63.5 ± 10.6

57.3 ± 11.6

< 0.001

Months after varices diagnosis, median (IQR)

25 (9–45)

15 (1–38)

14.5 (3.8–29.3)

16.5 (5.3–25.8)

0.27

First year after varices diagnosis, No. (%)

14 (28.6)

23 (46.9)

14 (46.7)

9 (37.5)

0.23

Months after varices bleeding, median (IQR)

20 (1–38)

0.5 (0–22)

4 (0.5–19.5)

5 (0.8–21.8)

0.15

First year after varices bleeding, No. (%)

11 (47.8)

12 (66.7)

9 (69.2)

7 (70)

0.45

Transplanted, No. (%)

2 (2.3)

5 (4.4)

0 (0)

0 (0)

1 MASLD vs. other

Hepatocellular carcinoma, No. (%)

3 (3.4)

6 (5.3)

1 (1.6)

1 (1.6)

1 MASLD vs. other

MELD-Na score*

22 (16–26.5)

21 (14.8–31.3)

29 (25.5–38.5)

30.5 (18.5–39.8)

0.01

22 (16–26.5)

 

26 (17–36)

 

0.02 MASLD vs. other

  1. MELD model for end-stage liver disease, MASLD metabolic dysfunction-associated steatotic liver disease.
  2. *Peak MELD-Na score achievable 1 year before and after first event of varices bleeding, median (IQR).
  3. Significant values are in bold.