Table 4 Cox regression analysis: association between liver disease etiology and survival, non-stratified and stratified by MELD-Na scores.

From: MELD-Na score may underestimate disease severity and risk of death in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)

 

Unadjusted HR (95% CI)

p-value

Model 1 HR (95% CI)

p-value

Model 2 HR (95% CI)

p-value

No stratification

 ALD, VH and both (reference)

  MASLD

1.43 (1.01–2.01)

0.04

1.2 (0.84–1.72)

0.32

1.67 (1.15–2.41)

< 0.01

MELD-Na 6–10

 ALD, VH and both (reference)

  MASLD

1.01 (0.22–4.59)

0.99

1.02 (0.96–4.37)

0.94

1.49 (0.31–7.26)

0.61

MELD-Na 11–20

 ALD, VH and both (reference)

  MASLD

2.84 (1.42–5.65)

< 0.01

1.99 (0.94–4.20)

0.07

2.06 (0.97–4.41)

0.06

MELD-Na 21–30

 ALD, VH and both (reference)

  MASLD

1.30 (0.71–2.38)

0.40

1.03 (0.54–1.96)

0.94

1.32 (0.65–2.66)

0.44

MELD-Na 31–40

 ALD, VH and both (reference)

  MASLD

1.08 (0.56–2.11)

0.82

1.02 (0.52–1.98)

0.97

1.43 (0.70–2.94)

0.33

  1. Model 1: adjusted for age.
  2. Model 2: adjusted for age, CKD, serum albumin and sodium.
  3. HR hazard ratio, MELD model for end-stage liver disease, ALD alcoholic liver disease, VH viral hepatitis, MASLD metabolic dysfunction-associated steatotic liver disease.
  4. Significant values are in bold.
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