Figure 2 | Scientific Reports

Figure 2

From: Cornification of keratinocytes is associated with differential changes in the catalytic activity and the immunoreactivity of transglutaminase-1

Figure 2

Immunodetection for TGM1 is reduced whereas transglutaminase activity persists in terminally differentiated keratinocytes in human epidermis. TGM activity and TGM1 immunofluorescence double-labeling was performed on sections of normal human skin (a) and lesional skin from patients with psoriasis (b). A white frame marks a detail of the image that is shown below at higher magnification (*). Note that normal skin (n = 3) and psoriatic skin (n = 5) were sampled in independent studies involving different body sites and storage of samples. Consequently, normal and psoriatic skin were investigated separately, and comparative analyses of healthy versus psoriatic skin were not performed. White arrows indicate cells of the uppermost layer of the living epidermis in which the TGM1 immunofluorescence signal is diminished or largely reduced, whereas TGM activity labeling is strong.

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