Table 3 Distribution of genotypic, allelic frequencies, and genetic models of rs4953616 and rs7371084 polymorphisms between PCOS cases and controls.
From: Significance of LHCGR polymorphisms in polycystic ovary syndrome: an association study
SNP | Genotype/allele | Case (%) | Control (%) | χ2 p-value | OR (95% CI) | p-value |
|---|---|---|---|---|---|---|
rs4953616 | CC | 92 (21) | 100 (26.3) | 1.0E−2* | Reference | – |
CT | 217 (49) | 198 (52.1) | 1.19 (0.84 to 1.67) | 0.3 | ||
TT | 134 (30) | 82 (21.6) | 1.77 (1.19 to 2.63) | 4.0E−3* | ||
C | 401 (45.3) | 398 (52.4) | 4.0E−3* | Reference | – | |
T | 485 (54.7) | 362 (47.6) | 1.3 (1.09 to 1.61) | 4.0E−3* | ||
Dominant model | TT + CT vs. CC | 351/92 | 280/100 | 0.06 | 1.3 (0.98 to 1.88) | 0.06 |
Recessive model | TT vs. CT + CC | 134/309 | 82/298 | 4.0E−3* | 1.5 (1.14 to 2.16) | 5.0E−3* |
Heterozygous model | CT vs. TT + CC | 217/226 | 198/182 | 0.3 | 0.8 (0.67 to 1.16) | 0.3 |
rs7371084 | TT | 397 (89.6) | 329 (86.5) | 0.25 | Reference | – |
TC | 42 (9.4) | 49 (13) | 0.7 (0.45 to 1.09) | 0.1 | ||
CC | 4 (1) | 2 (0.5) | 1.6 (0.30 to 9.10) | 0.5 | ||
T | 836 (94.4) | 707 (93) | 0.26 | Reference | – | |
C | 50 (5.6) | 53 (7) | 0.7 (0.53 to 1.18) | 0.2 | ||
Dominant model | CC + TC vs. TT | 46/397 | 51/329 | 0.1 | 0.74 (0.48 to 1.14) | 0.17 |
Recessive model | CC vs. TC + TT | 4/439 | 2/378 | 0.5 | 1.7 (0.31 to 9.45) | 0.5 |
Heterozygous model | TC vs. CC + TT | 42/401 | 49/331 | 0.1 | 0.7 (0.45 to 1.09) | 0.12 |
