Figure 7 | Scientific Reports

Figure 7

From: A machine learning approach toward automating spatial identification of LAG3+/CD3+ cells in ulcerative colitis

Figure 7

Implementation of the semi-automated pipeline on a cohort of ulcerative colitis biopsies. (a) total cells identified in the lamina propria and crypts. (b) CD3+, (c) LAG3+, (d) CD3+/LAG3+, (e) CD3-/LAG3+ cells identified within the tissue sub-compartments. (f) Correlation of CD3+ T-cells in the lamina propria versus crypt. (g) Correlation of CD3+/LAG3+ cells in the lamina propria versus crypt (one subject was removed due to high false positive LAG3 identification, Grubbs’ test: G = 3.893). N = 18 pinch biopsies, ** denotes p, 0.01, *** p < 0.001, **** p < 0.0001.

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