Figure 1 | Scientific Reports

Figure 1

From: Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion

Figure 1

G⍺12 is upregulated in high grade glioblastoma tumor samples and GSC cell lines. (A) cBio oncoprint from TCGA PanCancer GBM study. Genomic alterations in GNA12 and predicted G⍺12-coupled GPCRs. Z-scores relative to diploid samples RNA-Seq V2 RSEM: ± 1.5 threshold. (B) G⍺12 upregulation in GBM. RNA-Seq sample counts from Gliovis, p < 0.001. (C) Heatmaps of RNA-seq, whole exome, and additional clinical phenotype data aggregated from TCGA. (D) G⍺12 mRNA expression relative to neural stem cells in GSC cell lines.

Back to article page