Figure 1
Col- and CFA-induced mechanical hypersensitivity in male mice. (A) Schematic representation for pain conditions phases after CFA injection into MM. (B) Mechanical hypersensitivity at 1d and 5d post-CFA injected intro-MM in male mice. Statistical analysis is 1-way ANOVA Bonferroni’s post-hoc test (# P < 0.0001; n = 8). (C) Schematic representation for pain conditions phases after Col injection into MM. (D) Mechanical hypersensitivity at 1d and 5d post-0.2U Col and 1d, 6d and 14d post 10U Col injected intro-MM in male mice. Statistical analysis is 1-way ANOVA Bonferroni’s post-hoc test (# P < 0.0001; n = 8). X-axis indicates time post injection and injected reagent. Y-axis shows mechanical threshold assessed by von Frey filaments in an orofacial area above MM using up-down approach.
