Table 2 IVW method and sensitivity analyses using WMA and MR-Egger method for the Mendelian randomization analyses of micro-nutrients and ADHD.

From: Appraising the role of circulating concentrations of micronutrients in attention deficit hyperactivity disorder: a Mendelian randomization study

Exposure

N SNPs*

Method

OR

95% CI

P val

Magnesium

6

IVW

0.404

0.062–2.636

0.344

WMA

0.384

0.045–3.290

0.383

MR-Egger

5.016

0.014–18.33

0.621

Iron

10

IVW

1.061

0.967–1.163

0.212

WMA

1.083

0.973–1.206

0.143

MR-Egger

1.079

0.926–1.257

0.361

Copper

129

IVW

0.980

0.963–0.998

0.031

WMA

0.979

0.948–1.011

0.189

MR-Egger

0.972

0.938–1.007

0.123

Zinc

7

IVW

1.011

0.950–1.076

0.725

WMA

1.015

0.936–1.101

0.716

MR-Egger

1.076

0.855–1.355

0.558

Selenium

11

IVW

1.041

0.989–1.095

0.123

WMA

1.005

0.942–1.072

0.885

MR-Egger

1.027

0.856–1.232

0.780

Folate

8

IVW

1.282

0.898–1.829

0.171

WMA

1.214

0.759–1.951

0.414

MR-Egger

2.493

0.960–6.476

0.110

Vitamin A

7

IVW

2.628

0.003–2348.8

0.780

WMA

1.141

0.0002–5641.4

0.976

MR-Egger

0.068

6.93E-10–6,636,867

0.786

Vitamin B12

7

IVW

0.936

0.819–1.070

0.333

WMA

0.869

0.729–1.035

0.115

MR-Egger

0.869

0.689–1.096

0.290

Vitamin D

94

IVW

1.071

0.939–1.219

0.304

WMA

1.206

0.98–1.485

0.077

MR-Egger

1.088

0.89–1.329

0.412

  1. OR odds ratio, CI confidence interval, SNP single nucleotide polymorphism, IVW inverse-variance weighted, WMA weighted median approach.
  2. *The SNPs of magnesium, selenium, vitamin B12 and vitamin D were P < 5 × 10–8; the SNPs of iron, vitamin A, zinc and folate were P < 5 × 10–6; the SNPs of copper was P < 5 × 10–4.
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