Table 2 ROC curve analyses for the serum HO-1 level and other parameters to predict 3-month mortality among patients with acute exacerbation.

From: Serum heme oxygenase-1 as a prognostic biomarker in patients with acute exacerbation of interstitial lung disease

Variable

N

AUC

Best cut-off value

Sensitivity, %

Specificity, %

P value

Serum HO-1, ng/mL

51

0.71

41.8

62

74

0.016

P/F ratio

39

0.58

198

50

78

0.793

Serum LDH, U/L

51

0.59

336

54

71

0.446

Serum SP-D, ng/mL

46

0.41

1280

15

100

0.384

Serum KL-6, U/mL

50

0.71

406

54

84

0.043

Honeycomb score

51

0.55

3

85

39

0.891

GGO score

51

0.63

8

92

34

0.137

  1. AUC, area under the receiver-operating characteristic curve; GGO, ground-glass opacity; HO-1, heme oxygenase-1; KL-6, Krebs von den Lungen-6; LDH, lactate dehydrogenase; P/F, partial pressure of oxygen in arterial blood/fraction of inspiratory oxygen; SP-D, surfactant protein-D.
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