Figure 2 | Scientific Reports

Figure 2

From: Mass spectrometry in cerebrospinal fluid uncovers association of glycolysis biomarkers with Alzheimer’s disease in a large clinical sample

Figure 2

General upregulation of glycolytic enzymes is observed in AD CSF. (A) UpSet plot showing an overview of the differentially expressed peptides between DEM-AD and any non-AD group. The 33 peptides that were differentially abundant between DEM-AD and all non-AD group is highlighted in light blue. (B) Schematic representation of the peptide coverage of ALDOA and PKM in the MS data. Boxplots indicate the MS-intensity levels of 2 selected peptides from ALDOA and PKM each that were differentially expressed in an AD enriched pattern. Red lines indicate the mean. (C) Selected cluster from the STRING-DB analysis highlighting the enrichment of proteins involved in energy metabolism in AD CSF. Blue indicates proteins from the GO-term “canonical glycolysis”.

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