Figure 4 | Scientific Reports

Figure 4

From: Mass spectrometry in cerebrospinal fluid uncovers association of glycolysis biomarkers with Alzheimer’s disease in a large clinical sample

Figure 4

Levels of glucose, lactate and HbA1c in CSF in relation to glycolytic enzymes. (A) Levels of glucose and lactate in CSF across groups. CSF glucose levels were only found to be downregulated in MCI-AD compared to MCI-other. CSF lactate levels were not found to be significantly differentially abundant between any diagnostic group (*: Pearson’s correlation p < 0.05). (B) Protein level MS intensities for ALDOA and PKM showed a significant negative correlation with the CSF glucose levels. A negative trend was observed between CSF lactate and ALDOA and PKM protein abundance, but this trend did not reach significance. (C) No correlation was observed between peripheral glucose metabolism marker HbA1c and MS intensities for ALDOA and PKM proteins.

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