Figure 5 | Scientific Reports

Figure 5

From: Mass spectrometry in cerebrospinal fluid uncovers association of glycolysis biomarkers with Alzheimer’s disease in a large clinical sample

Figure 5

General elevation of glycolytic enzymes in AD is observed in both CSF and brain tissue. Heatmap representation of protein abundance of glycolytic enzymes measured in our CSF dataset and from a publicly available tissue dataset. Levels of ALDOA, PGK1, ENO1, PKM and LDHA were significantly upregulated in DEM-AD compared to CU in CSF. In tissue, GPI, PGK1 and PKM were significantly upregulated in AD compared to Controls (*: post hoc Tukey test p < 0.05). Protein abundances were scaled within each dataset and colors represent relative protein abundance. Gray boxes indicate proteins that were not robustly quantified in CSF or tissue.

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