Figure 1

Weight variation and glycemia from 129 and 129sve 5LO^−/− mice treated or not with captopril. (A) Body weight of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. (B) Blood glucose measurement of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. The body weight of the mice was evaluated throughout the T1D induction protocol and treatment with Cap. Blood glucose was checked 10 days after the last dose of STZ to confirm the T1D induction and 4 weeks after Cap treatment. Mice that presented weight loss together with blood glucose over 300 mg/dL were considered diabetic. n = 5–7 animals per group. Data are displayed as mean ± SEM. Different superscripts lowercase letters means statistical significance, with p being at least < 0.05. One-way ANOVA followed by Bonferroni post-test was used to analyze this set of data.