Figure 6

Effects of captopril on the expression of insulin signaling pathway markers in the muscle from 129 and 129sve 5LO^−/− mice. (A,B) Insr gene expression in the muscle of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. (C,D) Irs1 gene expression in the muscle of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. (E,F) Glut4 gene expression in the muscle of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. (G,H) Ampk gene expression in the muscle of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. Insr, Irs1, Glut4, and Ampk gene expression was analyzed using muscle homogenate from the groups mentioned. n = 4–8 mice per group. Data are displayed as mean ± SEM. Different superscripts lowercase letters means statistical significance, with p being at least < 0.05. One-way ANOVA followed by Bonferroni post-test was used to analyze this set of data.