Figure 8

Effects of captopril on the expression of autophagy markers in the muscle from 129 and 129sve 5LO^−/− mice. (A,B) Beclin1 gene expression in the muscle of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. (C,D) Atg5 gene expression in the muscle of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. (E,F) Atg7 gene expression in the muscle of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. (G,H) Atg12 gene expression in the muscle of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. (I,J) Atg14 gene expression in the muscle of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. (K,L) Lc3 gene expression in the muscle of Wt, Cap, T1D, T1D + Cap, 5LO^−/−, 5LO^−/− + Cap, 5LO^−/− T1D and 5LO^−/− T1D + Cap mice groups. Beclin1, Atg5, Atg7, Atg12, Atg14, and Lc3 gene expression was analyzed using muscle homogenate from the groups mentioned. n = 4–6 mice per group. Data are displayed as mean ± SEM. Different superscripts lowercase letters means statistical significance, with p being at least < 0.05. One-way ANOVA followed by Bonferroni post-test was used to analyze this set of data.