Figure 6 | Scientific Reports

Figure 6

From: Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis

Figure 6The alternative text for this image may have been generated using AI.

Inhibitor-FMT attenuated the symptoms of AOM/DSS-induced CAC. (A) Weekly body weight changes following AOM/DSS treatment. N = 10 ~ 20 per group. (B) Gross pathology and (C) size distribution of colorectal tumors of mouse colons at 10 weeks postinduction. N = 5 ~ 10 per group. (D) H&E staining of mouse colon sections and (E) histologic inflammation scores of colon tissues in mice at 17 days postinduction. Scale bar 50 μm. The arrows indicate the inflammatory cells infiltrating in the epithelium. N = 6 per group. (F) ELISA of IL-6 and TNF-α serum levels in mice at 17 days and 10 weeks postinduction. N = 4. All data are expressed as the Means ± SEM of each group. *P < 0.05; **P < 0.01; ***P < 0.001vs CAC. ƒP < 0.05; ƒƒP < 0.01; ƒƒƒP < 0.001vs NC-FMT. §P < 0.05; §§P < 0.01; §§§P < 0.001vs CAC-FMT. †P < 0.05; ††P < 0.01; †††P < 0.001vs Inhibitor-SFF. Data from Inhibitor-FMT group is shown in red; data from Inhibitor-SFF group is shown in blue.

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