Figure 1
Sox8−/− mice show increased weight loss and impaired motor function upon toxic demyelination. Mice received a 0.2% cuprizone diet for 5 weeks and were fed normal chow for 7 additional days. The dashed line indicates the termination of cuprizone treatment (timepoint of full demyelination and the starting point of remyelination processes). (A) Concerning weight change compared to day 0 (start of cuprizone diet), Sox8−/− mice (red) suffered from increased weight loss during cuprizone diet compared to WT controls (black). (B) The time of fall from an accelerating rod of Sox8-/- or WT mice before cuprizone treatment (naïve), at the time point of full demyelination (wk 5) and during remyelination (wk 5.5) revealed an increased motor deficit in naïve and cuprizone treated Sox8−/− mice. Bars represent mean, error bars show SEM.
