Table 1 Tag-free rhMFG-E8 does not cause acute or chronic toxicity in healthy mice.
From: Human cell-expressed tag-free rhMFG-E8 as an effective radiation mitigator
Assessment | Baseline | rhMFG-E8 (2 mg/kg), Day 0 | ||
|---|---|---|---|---|
Day 1 | Day 7 | Day 28 | ||
AST (IU/L) | 21.2 ± 4.8 | 29.3 ± 10.6 | 13.8 ± 4.0 | 18.8 ± 0.3 |
ALT (IU/L) | 3.7 ± 1.4 | 2.7 ± 2.1 | 2.4 ± 1.3 | 3.3 ± 1.6 |
LDH (U/L) | 19.0 ± 11.3 | 52.9 ± 45.9 | 10.8 ± 5.1 | 27.6 ± 11.1 |
Creatinine (mg/dL) | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.02 |
BUN (mg/dL) | 20.6 ± 2.3 | 21.8 ± 2.6 | 20.7 ± 2.2 | 24.7 ± 0.5 |
TNF-α (pg/ml) | 1.2 ± 0.3 | 2.0 ± 0.5 | 1.7 ± 0.3 | 2.0 ± 0.1 |
IL-6 (pg/ml) | 4.3 ± 0.8 | 11.4 ± 2.3 | 6.1 ± 1.1 | 8.0 ± 1.8 |
